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A good guide is always last season's points.
Also note how the most expensive keepers points compare to the cheaper ones.
If you plan to go 3 at the back then there is little point in having 5 top defenders.

Kane
De Bruyne
Alli

Cheers DJ

Plan is to go 3 at back and 2 up top

Have Lacacette and want either lukaku or Kane to partner

5 across the middle most weeks so I have a choice of De Bruyn or silva budget wise.

You'll probably need 2 players in there to make up the numbers, players you'll hopefully rarely if ever need yet will allow you to fit in more who'll earn you decent hauls.

Try to consistently have 3-4 midfielders who score or create chances whether it's from open play or set pieces. Midfielders tend to be the highest points scorers.

Kane
Silva
Ozil

Both
KDB
Neither

Kane
KDB
Alli