comment by Cinciwolf----JA606 NFL Fantasy Champion 2019----No Emotional Attachments....five long years (U11551)
posted 5 minutes ago
comment by peks..#masks4all (U6618)
posted 20 minutes ago
comment by Cinciwolf----JA606 NFL Fantasy Champion 2019----No Emotional Attachments....five long years (U11551)
posted 10 minutes ago
comment by peks..#masks4all (U6618)
posted 9 minutes ago
https://abc7news.com/coronavirus-drug-covid-19-malaria-hydroxychloroquine/6079864/
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Well fingers crossed this does turn out to be effective, it would be a game changer
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needs to be given early on in the disease though to be effective...not at the point someone is put in ICU
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That link says the complete opposite?!
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i've read other papers that suggest the earlier in the disease progression it is taken the better

comment by Amanda Hugginkiss (U11574)
posted 1 minute ago
comment by Cinciwolf----JA606 NFL Fantasy Champion 2019--... (U11551)
posted 17 seconds ago
comment by peks..#masks4all (U6618)
posted 1 minute ago
comment by Edward Elizabeth Hitler. (U14393)
posted 3 minutes ago
comment by peks..#masks4all (U6618)
posted 1 minute ago
i work as an industrial chemist, including research

i'm used to reading scientific papers , and seeing which ones are peer reviewed and decent, and not just utter shiiiite

i've been following this virus since it first emerged in china , and the progress being made with treatments, and knowledge of the disease

the Uk Gov have been consistently behind the knowledge curve imo
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Any ideas as to it just destroys some people and not others , I'm on about regular healthy people ?
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as stated above ..viral load
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Is that just the strength of the virus, as in each individual has different amounts of virus in their body?
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Number of viral particles the person carries. Someone who's heavily exposed to the virus for a long period will carry a much higher viral load than someone who just passes by another carrier in the corridor. Higher viral load > more severe infection. That's how it worked with SARS and MERS, both of which are coronaviruses too
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That is how i figured but surely a virus multiplies in you anyway?

comment by Tamwolf (U17286)
posted 47 seconds ago
comment by peks..#masks4all (U6618)
posted 6 minutes ago
comment by Edward Elizabeth Hitler. (U14393)
posted 3 minutes ago
comment by peks..#masks4all (U6618)
posted 1 minute ago
i work as an industrial chemist, including research

i'm used to reading scientific papers , and seeing which ones are peer reviewed and decent, and not just utter shiiiite

i've been following this virus since it first emerged in china , and the progress being made with treatments, and knowledge of the disease

the Uk Gov have been consistently behind the knowledge curve imo
----------------------------------------------------------------------
Any ideas as to it just destroys some people and not others , I'm on about regular healthy people ?
----------------------------------------------------------------------
as stated above ..viral load
----------------------------------------------------------------------

Is that actually the case though? I thought when it was looked into, they have found people who are asymptomatic with a high viral load.
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Weird thing about COVID-19 is that it doesn't seem to be 100% cut and dried. High viral load definitely plays a part in infection severity, but equally, different people seem to react differently irrespective of viral load. There seem to be genetic factors involved too.

I definitely think viral load is ONE factor though, albeit probably not the only one. There's also the fact that so many people have been infected that eventually some otherwise-healthy people are going to die too - just on the law of averages. They may also have underlying conditions that no-one knew about or tested for.

Well i have some old world war two coins in a drawer somewhere made of zinc so i am gonna give them a shot.

comment by Cinciwolf----JA606 NFL Fantasy Champion 2019--... (U11551)
posted 43 seconds ago
comment by Amanda Hugginkiss (U11574)
posted 1 minute ago
comment by Cinciwolf----JA606 NFL Fantasy Champion 2019--... (U11551)
posted 17 seconds ago
comment by peks..#masks4all (U6618)
posted 1 minute ago
comment by Edward Elizabeth Hitler. (U14393)
posted 3 minutes ago
comment by peks..#masks4all (U6618)
posted 1 minute ago
i work as an industrial chemist, including research

i'm used to reading scientific papers , and seeing which ones are peer reviewed and decent, and not just utter shiiiite

i've been following this virus since it first emerged in china , and the progress being made with treatments, and knowledge of the disease

the Uk Gov have been consistently behind the knowledge curve imo
----------------------------------------------------------------------
Any ideas as to it just destroys some people and not others , I'm on about regular healthy people ?
----------------------------------------------------------------------
as stated above ..viral load
----------------------------------------------------------------------

Is that just the strength of the virus, as in each individual has different amounts of virus in their body?
----------------------------------------------------------------------
Number of viral particles the person carries. Someone who's heavily exposed to the virus for a long period will carry a much higher viral load than someone who just passes by another carrier in the corridor. Higher viral load > more severe infection. That's how it worked with SARS and MERS, both of which are coronaviruses too
----------------------------------------------------------------------

That is how i figured but surely a virus multiplies in you anyway?
----------------------------------------------------------------------
Yes, but the more there is to start with, the less your immune system can fight off in the first place. Which would kinda explain why people can get very sick, very quickly when their immune system "runs out", so to speak

Yeah, i kind of assumed that those that die get sick relatively quickly as their bodies don't hold of the virus very well as opposed to the virus taking a week or more to start getting worse. No idea if that is the case though.

Yeah. I'm not medically trained, or anything. Just trying to phrase it in the layman's terms I can personally understand, having done some reading around. Course, the above all being said, I think the only cast-iron truth at the minute is that no-one knows exactly why some people get so badly affected. There are aggravating factors - age, respiratory conditions etc - but those don't explain the anomalies like the healthy 13 year old kid who died the other day. Could be viral load, could be some weird combination of chromosomes, could be an undiscovered underlying condition common to all the anomalous deaths, could be a combination of all the above. Who knows.

I agree, viral load only explains some of it. I’m sure there must be an underlying risk factor or protective factor that is endogenous to those infected that explains the almost bizarrely wide symptom spectrum. And why children are less affected.

My friend and colleague told me there are some papers that suggest Ang2 receptors present on pneumocytes (lung cells) may be a risk factor. With the amount of research going in i’m sure we’ll have sure answers in coming years of exact biochemical or genetic risk factors.

So pretty much it pot luck on how badly you may get this or not.

758 Deaths announced today in the UK on skynews , has not even peaked yet apparently.

Well there are the overt, obvious risk factors that will impact on symptom severity, but they’re risk factors for increasing severity/incidence of any disease. Being old, obese, smoker, immunocompronised, diabetic, any chronic illness. If you don’t have those if you get it you’ll probably be fine.

But there is still that relatively large minority of previously fit and healthy people that are 50-60 and below and below getting moderate-severe symptoms. Even some who perhaps haven’t had a high viral load. That’s surprised me

comment by Kunta Kante (U1641)
posted 5 minutes ago
Well there are the overt, obvious risk factors that will impact on symptom severity, but they’re risk factors for increasing severity/incidence of any disease. Being old, obese, smoker, immunocompronised, diabetic, any chronic illness. If you don’t have those if you get it you’ll probably be fine.

But there is still that relatively large minority of previously fit and healthy people that are 50-60 and below and below getting moderate-severe symptoms. Even some who perhaps haven’t had a high viral load. That’s surprised me
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I’m finishing my last pack of tobacco and then stopping smoking, better to be safe than sorry

comment by Edward Elizabeth Hitler. (U14393)
posted 10 minutes ago
758 Deaths announced today in the UK on skynews , has not even peaked yet apparently.
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Could be high from unreported cases over the weekend

comment by Edward Elizabeth Hitler. (U14393)
posted 15 minutes ago
758 Deaths announced today in the UK on skynews , has not even peaked yet apparently.
----------------------------------------------------------------------
That's the figures for England only.

With most viruses when you develop symptoms that is when your body starts fighting it, so that is generally a good thing right?. So with coronavirus, if you develop symptoms early on would you be more likely to fight off the disease? Or it’s impossible to say due to viral loading

comment by The Hybrid Doos (U10416)
posted 5 minutes ago
comment by Kunta Kante (U1641)
posted 5 minutes ago
Well there are the overt, obvious risk factors that will impact on symptom severity, but they’re risk factors for increasing severity/incidence of any disease. Being old, obese, smoker, immunocompronised, diabetic, any chronic illness. If you don’t have those if you get it you’ll probably be fine.

But there is still that relatively large minority of previously fit and healthy people that are 50-60 and below and below getting moderate-severe symptoms. Even some who perhaps haven’t had a high viral load. That’s surprised me
----------------------------------------------------------------------

I’m finishing my last pack of tobacco and then stopping smoking, better to be safe than sorry
----------------------------------------------------------------------
The smoking thing bothers me, but the again it doesn't. Let me explain...

I started smoking when I was 28. This is relatively late compared to a lot of people. Before then I genuinely got one serious cold per year. Since I have smoked I haven't had a single cold. Of course I know smoking is bad for me.

I haven't had even the slightest symptom of Covid and I am out every day except Sundays, being a keyworker. It does worry me though that there is no specific advice for smokers.

There is little advice for anyone, the information has been awful in the UK and the US.

comment by Amanda Hugginkiss (U11574)
posted 1 hour, 35 minutes ago
comment by Cinciwolf----JA606 NFL Fantasy Champion 2019--... (U11551)
posted 17 seconds ago
comment by peks..#masks4all (U6618)
posted 1 minute ago
comment by Edward Elizabeth Hitler. (U14393)
posted 3 minutes ago
comment by peks..#masks4all (U6618)
posted 1 minute ago
i work as an industrial chemist, including research

i'm used to reading scientific papers , and seeing which ones are peer reviewed and decent, and not just utter shiiiite

i've been following this virus since it first emerged in china , and the progress being made with treatments, and knowledge of the disease

the Uk Gov have been consistently behind the knowledge curve imo
----------------------------------------------------------------------
Any ideas as to it just destroys some people and not others , I'm on about regular healthy people ?
----------------------------------------------------------------------
as stated above ..viral load
----------------------------------------------------------------------

Is that just the strength of the virus, as in each individual has different amounts of virus in their body?
----------------------------------------------------------------------
Number of viral particles the person carries. Someone who's heavily exposed to the virus for a long period will carry a much higher viral load than someone who just passes by another carrier in the corridor. Higher viral load > more severe infection. That's how it worked with SARS and MERS, both of which are coronaviruses too
----------------------------------------------------------------------
Thats not what I understand. At least, its part of it, but I understand its how the body reacts to the virus. People with a balanced defence system dont get really sick because the anti bodies are released in just sufficient amounts to kill the virus. If you have an over active defence system it releases too many anti bodies which causes a severe reaction/infection and thats when people get into trouble.

comment by Edward Elizabeth Hitler. (U14393)
posted 1 hour, 34 minutes ago
758 Deaths announced today in the UK on skynews , has not even peaked yet apparently.
----------------------------------------------------------------------
Oh man.

It’s getting worse and worse, was hoping the numbers were beginning to go down

comment by Automatic For The People (U21889)
posted 4 minutes ago
comment by Edward Elizabeth Hitler. (U14393)
posted 1 hour, 34 minutes ago
758 Deaths announced today in the UK on skynews , has not even peaked yet apparently.
----------------------------------------------------------------------
Oh man.

It’s getting worse and worse, was hoping the numbers were beginning to go down
----------------------------------------------------------------------
Was chatting to my covid NHS data scientist mate on WhatsApp this morning. It's creating a tension between government and health bodies. As weekend reporting bottlenecks especially at weekends are causing folk Joe public to think corner has been turned only for a big catch-up number to appear during the week. It's fine for data scientists in NHS as they can account for it, but for publicly available daily reporting it's causing concern.

Scotland published 2,2 and 74 in recent days. Which is an extreme example of the issue.

I stopped looking at numbers last week for the most part, it just isn't worth it as they can be interpreted in so many ways.

comment by Cinciwolf----JA606 NFL Fantasy Champion 2019--... (U11551)
posted 1 hour, 5 minutes ago
There is little advice for anyone, the information has been awful in the UK and the US.
----------------------------------------------------------------------

The communication in the UK has been particularly bad. You expect it from the Trump administration but the govt has seemingly applied the typical bluster and ballacks they apply to everything else. While a good chunk of the population is worried about dying.

I understand that they don't have all the answers to this, but how they've communicated to people has not been good enough. Not good enough by half.

comment by Admin1 (U1)
posted 25 minutes ago
comment by Automatic For The People (U21889)
posted 4 minutes ago
comment by Edward Elizabeth Hitler. (U14393)
posted 1 hour, 34 minutes ago
758 Deaths announced today in the UK on skynews , has not even peaked yet apparently.
----------------------------------------------------------------------
Oh man.

It’s getting worse and worse, was hoping the numbers were beginning to go down
----------------------------------------------------------------------
Was chatting to my covid NHS data scientist mate on WhatsApp this morning. It's creating a tension between government and health bodies. As weekend reporting bottlenecks especially at weekends are causing folk Joe public to think corner has been turned only for a big catch-up number to appear during the week. It's fine for data scientists in NHS as they can account for it, but for publicly available daily reporting it's causing concern.
----------------------------------------------------------------------

comment by CEF (U3090)
posted 1 hour, 52 minutes ago
comment by The Hybrid Doos (U10416)
posted 5 minutes ago
comment by Kunta Kante (U1641)
posted 5 minutes ago
Well there are the overt, obvious risk factors that will impact on symptom severity, but they’re risk factors for increasing severity/incidence of any disease. Being old, obese, smoker, immunocompronised, diabetic, any chronic illness. If you don’t have those if you get it you’ll probably be fine.

But there is still that relatively large minority of previously fit and healthy people that are 50-60 and below and below getting moderate-severe symptoms. Even some who perhaps haven’t had a high viral load. That’s surprised me
----------------------------------------------------------------------

I’m finishing my last pack of tobacco and then stopping smoking, better to be safe than sorry
----------------------------------------------------------------------
The smoking thing bothers me, but the again it doesn't. Let me explain...

I started smoking when I was 28. This is relatively late compared to a lot of people. Before then I genuinely got one serious cold per year. Since I have smoked I haven't had a single cold. Of course I know smoking is bad for me.

I haven't had even the slightest symptom of Covid and I am out every day except Sundays, being a keyworker. It does worry me though that there is no specific advice for smokers.
----------------------------------------------------------------------
Just start vaping cheaper don't smell and I find it enjoyable.