I've presumed Disasi, Felix, Dewsbury-Hall, Chukwuemeka have left the club by that time.

Something needs to change in attack. I'd go for:

Jorgensen
James Chalobah Colwill Cucu
Caicedo Enzo
Palmer Nkunku Sancho
Jackson

Guiu needs to come on for Jackson when he's tired/struggling. Sick of Nkunku being wasted in that position. If anything we get worse when that change is made.

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For me, Madueke is not the one to drop at present.

Madueke is scoring, made a big leap improving on every attacking metric from last season, willing to use unfavoured foot and threatening with his dribbling into the box, like this consistently - https://video.twimg.com/amplify_video/1882896649116057600/vid/avc1/576x1024/4i-DF2YV6iMbWQAr.mp4?tag=14

OK, he's had lapse in concentration defending, but that shouldn't outweigh what he provides in attack at present. Sancho hasn't done anything worthwhile recently.

I would make the case to start all of Jackson, Madueke, Nkunku, Palmer at the moment.

Yeah I prefer Madueke over our other wide players as he’s got a goal in him but I wasn’t sure who to play down our left.